A study of sICAM-1,sVCAM-1 and sE-Selectin Profile in type II diabetes and latent autoimmune diabetes of adult. | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 256-269 PDF (0 K) | ||
| Authors | ||
| Sawsan M Jabbar Al-Hasnawi; Alaa Saad Al-Attabi; Zainab Abdu Al Ruda | ||
| Abstract | ||
| Intercellular adhesion molecule 1( ICAM-1) and vascular cell adhesion molecule VCAM-1 are members of the immunoglobulin superfamily bind to other members of the superfamily, to integrins or to a diverse range of additional counter-receptors. E-selectin which is presented on endothelial cells when its activated acutely. Serum levels of adhesion molecules like ICAM-1 measurement are possible after shedding of these molecules from active surface of endothelial cells and macrophages in diabetes patients following hyperglycemia as in patient with LADA and type II diabetes mellitus .So that this study was done for measuring serum level of ICAM-1,VCAM-1 and E-Selectin Profile in type II diabetes and latent autoimmune diabetes of adult and study their relation with level of HbA1C , gender , age ,BMI and complication of diabetes. In the study the serum of 36 patients with type2 diabetes mellitus ,34 patients with LADA and 20 healthy subjects test by ELISA technique for measuring the level of ICAM- 1,VCAM-1 and E-selectin . The study resulted in the mean sVCAM-1level of control group was significantly lower than D.M.2 and LADA group, P<0.05. The sE- Selectin level was higher in LADA group than control and D.M. type 2 group & significantly different when compared to control group (P<0.05). The sVCAM-1 level had a significant positive correlation (R=0.25, P=0.017) with BMI in all groups. High level of (sICAM-1,sVCAM-1 and sE-Selectin ) are associated with increased incidence of complication . | ||
| Keywords | ||
| ICAM; intercellular adhesion molecule; VCAM; vascular cell adhesion molecule; LADA; diabetes mellitus type | ||
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