Relationship between Transforming Growth Factor-Beta 1 gene polymorphism and hypertension | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 225-235 PDF (0 K) | ||
| Authors | ||
| Fadhil Jawad Al-Tu; Zena Abdul-Ameer Mahdi; Hassan Ali Nassrallah | ||
| Abstract | ||
| This study intends to evaluate the association between Transforming Growth Factor - Beta1 (TGF-β1) SNP codon 25 and hypertension in holy Kerbala city, Iraq. A case control study for one hundred and four subjects. Seventy four hypertensive patients (23 male and 51 female), already diagnosed with essential hypertension, and 30 control subjects (16 male and 14 female). The links between genotype and hypertension were examined then possible SNP related variances in the blood pressure were checked. The present study suggested that there is no significant association between transforming growth factor beta one (TGF-β1) and hypertension in its Iraqi population sample. However, there is a significant association between Arginine (Arg25) and hypertension compared with control group clearly shown in the male gender (p < 0.05). In this study, the associations between the SNP of TGF-β1 codon 25 and hypertension was not significant while the SNP showed genotype-related differences in gene allele (Arg25). | ||
| Keywords | ||
| Hypertension; TGF; gene; polymorphism | ||
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