;hfChanges in serum potassium and serum creatinine in hypertensive patients treated with Captopril with or without amlodipine | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 192-201 PDF (0 K) | ||
| Authors | ||
| Hassan A. A. Nassrullah; Kadhum Abbas Al- Hilaly; Haider Sobhy Al Hadad; Ali A.K. Abutiheen | ||
| Abstract | ||
| Background. Renal function and serum potassium are affected by many drugs. Angiotensin Converting Enzyme inhibitors and calcium channel blockers used to treat hypertension and non steroidal anti-inflammatory drugs used for musculoskeletal diseases. Those drugs affect both the renal function and the serum potassium. The aim of this study was to find the impact of these drugs on the renal function and serum potassium. Methods. A prospective study includes 60 patients in Al Hussain Teaching hospital in Kerbala. Sixty patients were involved in this study 27 male and 33 female, their age ranges between 41 and 65 years with a mean age of 52.98 years. All patients had hypertension and 34 of them had diabetes mellitus also. All patients started on captopril, 13 of them amlodipine added for them to control blood pressure, and 11 used none steroidal anti-inflammatory drugs. Serum potassium and serum creatinine were checked twice before starting treatment and the average value recorded and checked again after 3 months. Physical examination was done during the follow-up visits to look for symptoms and signs of hyperkalemia e.g. weakness, fatigability, parasthesia, or areflexia. Electrographic recording done to look for changes of hyperkalemia. Results. A significant increase in serum potassium and creatinine after starting treatment in the whole group. Regard the gender there were significant differences in both the serum potassium and serum creatinine in female patients but the differences were not significant in male patients. There was a significant difference in serum potassium in patients receiving captopril alone but not in serum Creatinine. There was difference in serum potassium and serum creatinine in the group of patients receiving captopril and amlodipine and statistically were significant. Changes were significant in diabetic patients but not in hypertensive patients. Conclusion. Captopril, amlodipine result in an increase in serum potassium and in serum creatinine in patients treated for hypertension. | ||
| Keywords | ||
| Captopril; Amlodipine; Non steroidal anti; inflammatory drugs; Serum potassium; Serum creatinine | ||
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