Derivative spectrophotometric method for estimation of Chlorphinramine Maleat in pure and its formulation Phenadone | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 179-191 PDF (0 K) | ||
| Authors | ||
| Al Samaraee; | ||
| Abstract | ||
| A simple, sensitive, economic, accurate and precise first (D1) and second (D2) derivative spectrophotometric method has been developed for determination of Chlorpheniramine maleate in pure and syrup form . The method obeys Beer’s Law in concentration range of 5-45μg/ml employed for evaluation . The quantitative determination of the drug was carried out using the first and second derivative values by measured ; peak to base line at ( 274 nm and 236 nm for first derivative) and (282 nm , 262 nm and 241 nm for second derivative ) , peak to peak at ( 274 nm – 263 nm for first derivative ) and ( 282 nm-262 nm and 262 nm – 241 nm for second derivative ) and peak area at ( 290 nm – 264 nm and 264 nm – 226 nm for first derivative ) and at (304 nm -274 nm , 274 nm – 254 nm , 254 nm – 232 nm for second derivative ) in 1:10% absolute ethanol: distal water . The results of analysis were validated by recovery studies . The recovery and RSD was ( 102.916-95.555 % ) and ( 0.751 – 0.006 %) respectively . The proposed method can be used for the routine quality control testing of the marketed formulations . | ||
| Keywords | ||
| First and second Derivative Spectrophotometry; Chlorpheniramine Maleat; phenadone | ||
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