Serum procalcitonin and plasma D-Dimer evaluation in pregnancy Conjugate with pre-eclampsia mild & severe pre-eclampsia versus normal pregnancy | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 166-178 PDF (0 K) | ||
| Authors | ||
| A. H; ; A. N; ; A. N; | ||
| Abstract | ||
| Pre- eclampsia is a common and heterogeneous syndrome of human pregnancy. Normal pregnancies are associated with inflammatory and hemostatic changes. The maternal syndrome of pre- eclampsia results from a systemic inflammatory response that involves the entire inflammatory network of the circulation, including the endothelium. Procalcitonin is an inflammatory marker which is raised in pre eclampsia .Normal pregnancy causes the maternal plasma DDimer level to increase progressively from conception until delivery .It is accepted that the hemostatic system is disturbed in pre eclamptic patients , but the effect or relationship with d dimer level and PET remains to elucidate . Aim of this study was to evaluate serum procalcitonin (PCT) , and plasma DDimer levels in mild and severe pre-eclampsia. Prospective case control study carried out in department of obstetrics and gynecology /Baghdad Teaching Hospital /Medical City /Baghdad /Iraq . Serum procalcitonin (PCT), and D-Dimer levels were determination in 40 cases with pre-eclampsia as the study group and 40 healthy pregnant women in the third trimester as the control group. Pre-eclamptic group consisted of mild (n = 20) and severe pre-eclamptic subgroup (n = 20). Laboratory results were compared between the groups and diagnostic usefulness of these parameters were evaluated. Serum procalcitonin (PCT) PCT, and D-Dimer levels were significantly higher in study group than the control group (P <0.001). PCT, and D-Dimer were significantly higher in the patients with severe pre-eclampsia than mild VIII preeclampsia( p=0.012)There were significant positive correlations between these markers and mean arterial pressure (MAP). Logistic regression analysis using the control and pre-eclampsia group showed that higher PCT (OR,6.12; 95%-CI, 3.30- 13.50), and D-Dimer levels (OR,4.41; 95%-CI,2.8-9.18)were found to be risk factors significantly associated with pre-eclampsia. This study results confirm that evidence of a possible exaggerated systemic inflammatory response in pre eclampsia especially in severe pre- eclampsia | ||
| Keywords | ||
| Pre; eclampsia; Serum procalcitonin; mean arterial pressure | ||
|
Statistics Article View: 53 PDF Download: 54 |
||