Total Antioxidant Capacity and Some Risk Factors in Iraqi Smokers with Acute Myocardial Infarction | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 150-156 PDF (0 K) | ||
| Authors | ||
| Fadhil J. Al-Tu; Riyadh D. Al-Zubaidi; Abdulmutalb B. M. Al-Khaleeli | ||
| Abstract | ||
| Background: Acute myocardial infarction (AMI) is one of the major causes of mortality and morbidity in the world. Reactive oxygen species (ROS) may play important role in the pathogenesis in myocardial infarction. Cigarette smoke is a major exogenous source of free radicals which is a heterogeneous aerosol consisting of more than 4000 compounds including high concentrations of free radicals, and reactive oxygen and nitrogen species. Total antioxidant capacity (TAC) was studied in most cases in serum, and may be used as a marker of the body antioxidant status. The recent applications of the TAC status in medical and nutritional studies as well as future possible uses of TAC level as a biomarker for diagnosis, prognosis and prevention of respiratory, diabetes, heart and vascular system, chronic renal injury, neurological, cancer diseases. Aim: Study the correlation between the total antioxidant capacity level with lipid profile changing Materials and Methods: This study was conducted during the period from Nov. 2014 to Sep. , 2015. Fifty eight patients presented with typical chest pain to the cardiac care unit in Al-Hussein Teaching Hospital, Al-Hussein Medical City/ Kerbela Health Directorate and Department of Biochemistry–College of Medicine / University of Kerbala. The diagnosis was based on the clinical history, presentation confirmed by ECG and various investigations of cardiac biomarker. Thirty five persons age – matched healthy volunteers were selected as a control group. The age, weight, height, lipid profile, TAC were measured in sera of all subjects Results: The results revealed that serum total cholesterol, triglyceride, VLDL-C and LDL-C were significantly increased (P < 0.01) but serum HDL-C level was significant decreased (P < 0.01) in non-smoker AMI patients as compared with that found in non-smoker controls, while serum TAC , BMI and age was non-significantly different between non-smoker patients and non-smoker healthy control groups (p > 0.05). The results of smoking AMI show non-significant differences in levels of total serum cholesterol, triglyceride, VLDL-C, LDL-C and a significantly decreased in serum HDLC as compared with smoker control. On the other hand BMI was non-significantly different between smoker patients and smoker healthy control groups (p > 0.05), while the results obtained show that a significant decrease in TAC in smoker AMI patient group in comparison with smoker normal control group (p < 0.05), and significant different age in smoker AMI patient group in comparison with smoker normal control group (p < 0.05). | ||
| Keywords | ||
| AMI; TAC; lipid profile; ROS | ||
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