Effect of thyroid peroxidase antibodies (TPO) on endometrium thickness (ET) - Ova size in infertile women in Kerbala a descriptive study | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 145-149 PDF (0 K) | ||
| Authors | ||
| Mousa M. Ali Al-Alak; Zahraa Sabbar Omran; Zina Hasan Abdul-Qahar | ||
| Abstract | ||
| Infertility is a disease of the reproductive system defined by failure achieve a clinical pregnancy or inability of a couple to conceive naturally after 12 months or more regular intercourse without contraception. Thyroid dysfunction can lead to menstrual disturbance, anovulatory cycle and decreased fertility. Autoimmune thyroid diseases are the most common autoimmune conditions encountered in females in reproductive age characterized by presence of antibodies against some structures of thyroid gland such as thyroid peroxidase (TPO); which is the key thyroid enzyme catalyzing both the iodination and coupling reaction for the synthesis of thyroid hormone. Anti-TPO autoantibodies are present in approximately 90% of patients with autoimmune thyroid diseases.The study aimed to evaluate the role of thyroid antibodies in subfertility patients on ova size and endometrium thickness. The study was conducted during the period from March 2015 to September 2015 at Karbala Maternity Hospital, infertility unit, and some private clinics. This study included a total number of 92 women in the reproductive age; ranging between (15- 43) years; divided patients into: primary infertility included (56); while secondary infertility were (36) infertility females. The following parameter were measured for all study groups: anti-TPO using ELISA device .Additionally, ultrasound was done to measure the ova size and endometrial thickness. The results showed a significant difference between primary and secondary infertility in TPO, when relation between TPO with ova size and endometrial thickness there is a significant difference between TPO and ova size in abnormal TPO and a significant difference between TPO and ET in abnormal TPO in infertile women. There is a relation between ova size and TPO, anti-TPO may be used as a biochemical indicator of subclinical thyroid disorders and may help in assessment of thyroid function as a cause of infertility whether primary or secondary. | ||
| Keywords | ||
| Infertility; thyroid peroxidase | ||
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