Sensitivity and specificity of Rheumatoid factor and anti-cyclic citrullinated protein antibody positivity in patients with rheumatoid arthritis in karbala city | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 110-115 PDF (0 K) | ||
| Author | ||
| Alaa Saad Al-Attabi | ||
| Abstract | ||
| Rheumatoid arthritis (RA) is systemic autoimmune disease of unknown etiology which characterize by joint and systemic involvement can lead to sever disability. The rheumatoid factor is one of the main serological test for diagnosis but is of low specificity since it is found in healthy people and other diseases . Anti- citrullinated protein antibody (anti-CCP) which is more specific and less sensitive is considered as another serological marker for diagnosis of RA. So that this was done to measure the sensitivity and specificity of RF and anti-CCP in patients with rheumatoid arthritis. The study included 260 patient with RA and 130 healthy subjects their sera were used for measuring RF by latex agglutination technique and measuring anti-CCP by ELISA technique. This study was found the sensitivity ,specificity , positive predictive value and negative predictive value for RF were (86.9%) , (96%) ,(97%)and (78%) respectively , while those for AntiCCP were 73% ,100% , (100%)and (65%) respectively. The p value for RF anti-CCP antibodies test was < 0.01 which indicate significant difference between patients and control group .So anti-CCP more specific and less sensitive than RF ,although it can be depended on RF for initial diagnosis , treatment and prevention of joint disabling .Seronegative patients did not exclude RA so must seek for another investigation such as anti-CCP. Measuring RFand anti-CCP at the same time increase sensitivity for diagnosis. | ||
| Keywords | ||
| Rheumatoid Arthritis; anti; CCP; rheumatoid factor and ACR; cyclic citrullinated; ACR | ||
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