Hepatoprotective activity of Artichoke (Cynara scolymus) against Paracetamol toxicity in female rats | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 36-43 PDF (0 K) | ||
| Authors | ||
| Msc.Amal umran musa; Msc. Shatha Hussein kadhim; Msc. Zahraa abed al- kreem; Msc. Moayad Mijbil ubaid | ||
| Abstract | ||
| Hepatotoxicity is an acute adverse effect of paracetamol overdose which could be fatal, so in this research we studied the effect of paracetamol on liver enzymes (GPT, GOT, total protein, glucose, bilirubin) of female rats that drenched Artichoke. twenty laboratory female rats housed in plastic cages in animal house at university Karbala of / college of pharmacy , the animals divided randomly into four groups ,(G1 control, G2 drenched with 500 mg/kg Artichoke and 500 mg/kg paracetamol, G3 drenched with 500 mg/kg paracetamol ,G4 drenched with 500 mg/kg Artichoke ) , the present study found the ability of Artichoke to protect liver enzyme against the poisonous effect of paracetamol by reducing the higher value of GPT,GOT, glucose, and evaluated the lower value of bilirubin and total protein causing by paracetamol. Histopathological changes in liver were greatly reduced on animals treated with artichoke and paracetamol when compared with the paracetamol group .However, animals treated with paracetamol showed severe congestion in central vein and there is inflammatory cell and degeneration in hepatocyte enlargement in sensoides and necrosis and odema. | ||
| Keywords | ||
| Artichoke; paracetamol; Liver enzymes | ||
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