Formulation &invitro evaluation of clarithromycin floating microsponge capsule | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 7, Issue 11, September 2016, Pages 27-35 PDF (0 K) | ||
| Authors | ||
| Jenan m. Mohsin al mosawi; Alaa Abdul- Razzaq; Hasanain Shakir Mahmood | ||
| Abstract | ||
| Objective: The aim of this study is to formulate microsponge of clarithromycin capsule dosage form and evaluate the release profile in comparing with marketed clarithromycin (Clamycin) Methods: clarithromycin microsponge was prepared by quasi-emulsion solvent diffusion method by using polymers Eudragite RL100 in organic solution as internal phase and aqueous solution of polyvinyl alcohol as external phase. The compatibility of the drug with formulated components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The prepared microsponge powder was evaluated for angle of repose, Carr's Index ,particle size, floating time production yield, drug loading efficiency of microsponges and release profile in comparison with marketed drug. Results: Formulation F4 with a ratio 8:1 drug to polymer, and 0.25% polyvinyl pyrrolodine solution was the best formulation showing the highest degree of sustained release that was 79.59% at the end of 12 hours with a floating time capsule 12 hr. Eudragit RL 100 could control drug release in stomach. | ||
| Keywords | ||
| Microsponges; clarithromycin; Quasi; emulsion solvent diffusion method | ||
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