Estimation of Aromatase Enzyme in Obese Infertile Men | ||
| Iraqi Journal of Embryos and Infertility Researches | ||
| Article 1, Volume 6, Issue 1, December 2016, Pages 22-31 | ||
| Authors | ||
| Ula M. AL-Kawaz; Nawal K. AL-Ani; Hikmat F. Wassef | ||
| Abstract | ||
| Background: Male obesity is associated with physiological changes that can negatively affect male fertility. Obese men have demonstrated a 3-fold increase in the prevalence of oligozoospermia when compared with men with normal Body Mass Index (BMI). Objective: To estimate the role of aromatase enzyme in decreasing sperm parameters in obese infertile men. Subjects, Materials and Methods: Seventy obese infertile male (patients) and twenty obese fertile male (control) are enrolled in this study. Seminal fluid analysis done according to criteria of WHO (2010). Results: A significant negative correlation was found between human cytochrome enzyme and sperm concentration, progressively motile sperm, non-progressively motile sperm, immotile sperm and normal morphology. Conclusion: The present study showed clearly that male obesity negatively impacts fertility through direct association between increased (BMI) and semen parameters. The results suggest that increased estrogen as a result of aromatization in the fatty tissue, reflected through the increase in human cytochrome enzyme (aromatase), may be an important mechanism for the hypoandrogenemia and altered sperm parameters | ||
| Keywords | ||
| Aromatase enzyme; Male infertility; Obesity; Sperm parameters | ||
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