Synthesis of some New Schiff Bases and Hydrazones Containing Benzonaphthyridine/ Benzonaphthyridone Moiety | ||
| Rafidain Journal of Science | ||
| Article 7, Volume 25, Issue 6, December 2014, Pages 56-69 PDF (0 K) | ||
| DOI: 10.33899/rjs.2014.131351 | ||
| Authors | ||
| Rafid K. Jameel; Attallah M. Sheat | ||
| Abstract | ||
| The N-(4-methyl-2-pyridyl)anthranilic acid (I) was synthesized by Ullmann condensation. The compound (I) was cyclized by polyphosphoric acid (PPA) to give 4-methyl-10H-benzo[b][1,8]naphthyridin-5-one (II). The compound (II) was treated with selenium dioxide (SeO2) and thionyl chloride (SOCl2) to give the 4-formyl-10H-benzo[b][1,8]naphthyridin-5-one (III) and 4-methyl-5-chloro-benzo[b][1,8]naphthyridine (IV) respectively. The compound (III) was reacted with various substituted anilines and aliphatic amines to give the Schiff bases (Va-j). The compound (IV) was reacted with hydrazine hydrate to yield the 5-hydrazino derivative (VI), which was reacted with various aromatic aldehydes to yield the hydrazones (VIIa-j) and the Rf values reported.The reaction progress was followed by thin layer chromatography (TLC). The synthesized compounds were confirmed by spectral data (I.R, 1H-NMR, 13C-MNR). The possible fragmentation pattern of GC/MS for the compounds (III), (Vc) and (VIIg) were reported. | ||
| Keywords | ||
| Benzonaphthyridine; Benzonaphthyridone; Schiff Bases; Hydrazones | ||
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