The Effect Study of Using Different Concentrations of Chocolate Brown Dye (Chocolate Brown HT E155) on Some Physiological Parameters and Histological Structure of Stomach and Intestine on Albino Rats | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 16, Issue 2, June 2016, Pages 24-35 PDF (0 K) | ||
| Author | ||
| Ahmed Jassim Hassan Hussein Abbas Salman | ||
| Abstract | ||
| The present study was conducted to check the effect of different doses of chocolate brown dye on some physiological parameters(SOD, GSTs and MDA), and the concentration of amine transfer enzymes (AST and ALT) and histological structure of stomach and intestines. The current study experience forming of 20 rats, divided into four major groups; consisted of each group from five animals which given each group a different concentration from chocolate brown dye concentration for six weeks, as follows: The first group (control group C) animals doses by normal drinking water, the second group (T1) animals doses by chocolate brown dye at the concentration of 200 mg/ kg of body weight, the third group (T2) animals doses by chocolate brown dye at the concentration of 400 mg/ kg of body weight and the fourth group (T3) animals doses by chocolate brown dye at the concentration of 600 mg/ kg of body weight. Results showed that a significant decreased (P<0.05 ) in body weight and the concentrations of antioxidant enzymes (SOD and GSTs) in exchange for a significant increase in MDA and amine transfer enzymes (AST and ALT) concentrations in animals groups (T1, T2 and T3) by increased the concentration of chocolate brown dye compared with control group animals, as well as, occur pathogenic textile changes in stomach and intestines of groups animals (T2 and T3) represented with necrosis, cell death in intestines and stomach an cases of hemorrhage in stomach endothelial layer induced by free radicals. It was concluded from this study that the high dose of chocolate brown dye have some negative effects on liver functions, some physiological parameters and histological structure of stomach and intestines. | ||
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