Fahmi Abbas, R., Amer Wheeb, A., Ala, , Abdullwahid Jasim, A. (2016). Spectrophotometric Determination of Doxycycline Hyclate in Pure and Capsule using Diazotization Reaction. Alustath, 27(5), 50-54.
Ruba Fahmi Abbas; Ali Amer Wheeb; Ala; a Abdullwahid Jasim. "Spectrophotometric Determination of Doxycycline Hyclate in Pure and Capsule using Diazotization Reaction". Alustath, 27, 5, 2016, 50-54.
Fahmi Abbas, R., Amer Wheeb, A., Ala, , Abdullwahid Jasim, A. (2016). 'Spectrophotometric Determination of Doxycycline Hyclate in Pure and Capsule using Diazotization Reaction', Alustath, 27(5), pp. 50-54.
Fahmi Abbas, R., Amer Wheeb, A., Ala, , Abdullwahid Jasim, A. Spectrophotometric Determination of Doxycycline Hyclate in Pure and Capsule using Diazotization Reaction. Alustath, 2016; 27(5): 50-54.

Spectrophotometric Determination of Doxycycline Hyclate in Pure and Capsule using Diazotization Reaction

Al-Mustansiriyah Journal of Science
Article 1, Volume 27, Issue 5, December 2016, Pages 50-54
Authors
Ruba Fahmi Abbas; Ali Amer Wheeb; ; a Abdullwahid Jasim
Abstract
A sensitive spectrophotometric method has been developed for the determination of Doxycycline hyclate (DCH) as pure and capsule forms. This method is based on diazotization of primary amine group of benzocaine with sodium nitrite in hydrochloric acid medium; the formed diazonium salt is then reacted with DCH in sodium hydroxide medium, to form yellow – orange Azo dye. Beer's law is obeyed in the concentration rang 16-34mg. ml-1 at 480 nm with detection limit LOD and molar absorptivity Є were found to be 0.418 mg.ml-1 and 2.214× 10+4 L.mol-1.cm-1, respectively.
Keywords
doxycycline Hyclate; Benzocaine; spectrophotometric; diazotization
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