Histopathological study in Lungs of mice implanted with mammary adenocarcinoma (AM3) and treated with flavonoids (apigenin) | ||
| journal of kerbala university | ||
| Article 1, Volume 10, Issue 3, September 2014, Pages 259-269 PDF (0 K) | ||
| Abstract | ||
| Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, had a role as anti-oxidant activity and regulate the redox status and prevent damage caused by oxidative stress. The present study aimed to investigate the hitopahtological changes may occurred in pulmonary tissues of mice implanted with mammary adenocarcinoma AM3 and treated with flavonoid. A sixty mice bearing-mice tumor and normal mice divided into G1; (n=3) bearing-AM3 tumor and treated with flavonoids (apigenin) 300mg/kg b.w/orally and daily/30 days, G2; (n=3) mice bearing-tumor only, G3; (n=5) mice treated with flavonoids (apigenin) 300mg/kg b.w/orally /30days, G4; (n=5) as control group treated with D.W. The results of hematoxylene and eosin stained tissues of lung revealed significant histologic changes in tumor-bearing mice of chronic bronchiolitis, interstitial pneumonia and alveolar emphysema, while in treated bearing-mice with flavonoid showed perivascular cuffing, no metastasis seen. | ||
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