Toxic Effect of Alcoholic and Alkaloids extracts of Melia azedarach plant in two cell lines | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 13, Issue 3, July 2017, Pages 77-90 | ||
| Authors | ||
| Maryam Hikmat Abdullatif; Ibrahim Hade Muhamed; Amer Talib Tawfiq | ||
| Abstract | ||
| In this study we showed effect of alcoholic and alkaloids crude extract of M.azedarach fruits on tumor cell lines HepG2, SK-GT2, and so using six concentration (12.5,25,50,100,200,400)mg/ml, and for a period of 24 hours exposure. Both extract revealed cytotoxicity on different cell line, and this effect depend on concentration and type of cells and extract.The inhibition activity for tumor cell line increas with increase concentration of extract. While found that tumor cell line type inhibition variance in both extract depending on cells differences.The lowest inhibition rate for alcoholic extract was 9.8% in concentration 12.5µgml, and higher inhibition rate was 59.2% in concentration 400µgml for HepG2, while for SK-GT2 the lowest inhibition rate was 4.3% for alcoholic extract in concentration 12.5µgml and higher inhibition rate was 36.3% in 400µgml. | ||
| Keywords | ||
| Cell line; Melia azedarach; Alkaloides; alcoholic extract | ||
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