P16INK4a Overexpression in Cervical Biopsies Collected from Women with Normal and Equivocal Pap Smears | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 29, Issue 1, March 2016, Pages 16-25 | ||
| Authors | ||
| Thanaa JM Al-Khishali; Nada Salih Ameen; Huda M Al-Khateeb | ||
| Abstract | ||
| Background: Cervical cancer is the third most common cancer among women worldwide Immunohistochemical expression of p16INK4a has been relatively well established in cervical biopsy specimens. Objectives: Our hypothesis is to evaluate the usefulness of p16 immunostaining on tissue sections in borderline cases. Methods: This is a case-control study with a total of cervical samples from 60 women (25-66 years age) divided into three groups (I, II and III). The study was conducted at the Colposcopy Clinic in Baghdad Teaching Hospital – Medical City Complex, during the period from June 2013 through July 2014. The samples were analyzed by cytopathology, histopathology and p16INK4a immunostaining. Results: Group I showed negative p16 reaction. Among group II; one (5%) showed mild positive, 9 (45%) moderate positive and 10 (50%) high positive reactions. Group III specimens showed p16 positivity. Conclusion: p16INK4a immunohistochemistry is one of the best candidates for histologically indeterminate lesions. | ||
| Keywords | ||
| INK; cervical cancer; Human papillomavirus; cervical intraepithelial neoplasia | ||
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