The neurobehavioral and withdrawal effects of diazepam in adult male rats | ||
| Kufa Journal For Veterinary Medical Sciences | ||
| Article 1, Volume 5, Issue 2, December 2014, Pages 306-318 | ||
| Authors | ||
| Mohammed Jawad kadhim; Falah Muosa Kadhim AL-Rekabi; Duriad Abdulhadi Abass | ||
| Abstract | ||
| The study conducted to evaluate the neurobehavioral effects and dependence in adult male rats which showed significant decrease (p<0.05) in exploration, vestibular system (increasing time of rotating on negative geotaxis apparatus), decrease cognition, short term memory, locomotors activity (decrease time of rotating on Rota rod apparatus), where these results was confirmed by histopathological changes of brain which represent by congestion, perivascular edema, focal gliosis and mononuclear cells infiltrations in groups treated with diazepam. The results of withdrawal study after one week of stop dosing of diazepam treatment showed signs of addiction represented by hyperactivity, restlessness, diarrhea and goose flesh in dose dependent manner. | ||
| Keywords | ||
| Neurobehavioral; withdrawal; Diazepam; male rat | ||
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