Laplace Transform based Prediction of Drug Concentration in Blood | ||
| Journal of College of Education | ||
| Article 1, Volume 0, Issue 5, November 2017, Pages 89-98 | ||
| Author | ||
| Jinan Fadhil Mahdi | ||
| Abstract | ||
| Performance of an oral dosage form like tablet or capsule is determined by the amount of drug present in the plasma at a given time. Prediction of this in-vivo performance in terms of concentration of drug in blood poses problems. A new technique called convolution which is based on system approach is presented with actual data and details of implementation of the convolution technique. This technique is of great relevance in advanced dosage forms having longer duration of performance like 12, 16 or 24 hours. In the design and development of oral products this technique allows for prediction of the plasma profile without conducting bio studied in human subjects that highly expensive and time consuming. | ||
| Keywords | ||
| concentration of drug in blood; convolution technique; absorption of drug; Convolution Integral | ||
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