Spectrophotometric determination of Chlorpromazine Hydrochloride by oxidative coupling reaction with P-Bromo aniline using Ammonium Ceric Sulphate Dihydrate | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 11, Issue 1, March 2016, Pages 1-19 PDF (0 K) | ||
| DOI: 10.32894/kujss.2016.124380 | ||
| Author | ||
| Israa T. Humeidy | ||
| Abstract | ||
| A new sensitive spectrophotometric method for the determination of chlorpromazine hydrochloride (CPZH) was developed. The method is based on an oxidative coupling reaction with p-bromoaniline using ammonium ceric sulphate dihydrate as oxidizing agent to produce a violet color, soluble in water, stable product and absorbs at 553 nm. Beer's law was in the linear range 2.5 - 30 μg/ml of CPZH, the molar absorptivity, Sandellʼs sensitivity index and detection limit were 6.5731 × 103 liter. mol-1.cm-1, 0.0541 μg.cm-2 and 0.1361 μg/ml respectively. The RSD value was 1.20 - 1.36 % depending on the concentration. This method was applied successfully to the determination of chlorpromazine hydrochloride in two pharmaceutical formulations (tablets and injection). | ||
| Keywords | ||
| spectrophotometric; CPZH; bromoaniline | ||
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