Coated Wire and Multiwalled Carbon Nanotube Composite Coated Wire Sensors for Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations. | ||
Journal of University of Anbar for Pure Science | ||
Article 6, Volume 8, Issue 3, December 2014, Pages 20-27 | ||
Document Type: Research Paper | ||
DOI: 10.37652/juaps.2014.123989 | ||
Authors | ||
Riyadh M. Jihad1; Ismael K. Al-Hitti2; Adawiya J. Hayder3 | ||
1University of Anbar - Education College for Women | ||
2University of Anbar - College of Science | ||
3University of Technology - Nanotechnology Center | ||
Abstract | ||
fabrication and performance characteristics of novel potentiometric sensors for the determination of chlorpromazine hydrochloride are described. The proposed sensors include a coated copper wire sensor and a multiwalled carbon nanotube (MWCNT) composite coated copper wire sensor. The sensors are based on the chlorpromazine-phosphotungstate ion associate as electroactive material. The developed sensors exhibited near nernstian slopes of 53.69 and 57.31 mV concentration decade-1 at 25 ◦C, in the concentration range 5.0 x 10-5 – 1.0 x 10-2 mol L-1 chlorpromazine hydrochloride with limits of detection of 4.8 x 10-5 and 4.9 x 10-5 mol L-1 chlorpromazine hydrochloride for coated copper wire sensor and a (MWCNT) composite coated copper wire sensor, respectively. The proposed sensors exhibited good selectivity for chlorpromazine with respect to a large number of inorganic cations, amino acid and sugars. The developed sensor was successfully applied for the potentiometric determination of chlorpromazine hydrochloride in the pharmaceutical preparations and human urine samples. | ||
Keywords | ||
chlorpromazine hydrochloride; Pharmaceutical Preparation; human urine; coated wire sensor | ||
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