Synthesis of Several New Schiff Bases Linked to Sulfonamido Naphthalimide Moiety with Expected Biological Activity. | ||
| Journal of University of Anbar for Pure Science | ||
| Article 15, Volume 8, Issue 2, August 2014, Pages 47-52 PDF (0 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2014.123915 | ||
| Authors | ||
| Ahlam Marouf Al-Azzawi1; Ahmed Solaiman Hamed* 2 | ||
| 1University of Baghdad - College of Science | ||
| 2University of Anbar- College of Veterinary Medicine | ||
| Abstract | ||
| Several new Schiff bases linked to sulfonamidonaphthalimide moiety have been synthesized. The first step in this work involved introducing of 4-(N-naphthalimidyl) phenyl sulfonylchloride in amination reaction with hydrazine hydrate producing 4-(N-naphthalimidyl) phenyl sulfonylhydrazine. Introducing of the prepared sulfonyl hydrazine in condensation reaction with different substituted aromatic aldehydes in the second step afforded the target new Schiff bases. Structures of the prepared compounds were elucidated on the basis of FTIR, 1HNMR, 13CNMR spectral data which agreed with the proposed structures. The newly synthesized compounds are expected to have biological activity scince they are built from biologically active components including naphthalimide, sulfonylimide and Schiff base. | ||
| Keywords | ||
| Naphthalimide; Sulfon amide; naphthalimidyl; Sulfonylhydrazine | ||
| References | ||
|
[1]Chandra K.B. and Kaushik A.J., (2012) pharmacological examination and synthesis of some Schiff bases and thiazolidinone derivatives of 5-amino-1H-imidazole-4-carboxamide,Der pharm chemical, 4(5) :1873-1878.
[2] Kumar P.P. and Rani B.L., (2011) Synthesis and characterization of new Schiff bases containing pyridine moiety and their derivatives as antioxidant agent, Int. J. chem. Tech. Res., 3(1): 155-160.
[3] Abdel-Salam F. H., (2010) Biological study and complextion behavior of some anionic Schiff base amphiphiles, J. Surfact. Deterg.,13:423-431
[4] Antia S. and Manish K. S., (2013) Synthesis, characterization and biological activity of Schiff bases derived from 3-(4-substiuted)-1-phenyl-1H-pyrazol-4-carbaldehyde and o-aminophenol, Chem. Sci. Trans., 2(3): 871-876.
[5] Satyanarayana V. S., Sreevani P., Sivakumar A. and Vijayakumar V., (2008) Synthesis and antimicrobial activity of new Schiff bases containing comarin moiety and there spectral characterization, ARKIVOC, xvii :221-223.
[6] Sathe B. S., Jayachandran E. and Jagrap V. A., (2011) Antithelmintic activity of newly synthesized moieties of fluorobenzothiazole Schiff's base, Res. J. Pharm. Bio. And Chm. Sci., 2: 510-515.
[7] Aibin W., Yufang X. and Xuhong Q., (2010) Novel naphthalimide-indomethacin hybridsas potential antitumor agents, Monatish chem.141: 393-899.
[8] Andricopulo A. D., Yunes R. A., Filho V. C., Correa R., Willain A., Santos A. R.S. and Nunes R. J., (1998) Synthesis and analgesic properties of cyclic imides , naphthalimide and bisnaphthalimide derivatives, Acta Farm. Bon., 17 :219-224.
[9] Tati Jana M., Tina M., Celine B., Nancy D. and Janique D., (2008) UNBS 5162 a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancer. Neoplasia, 10 :573-586.
[10] Santosh K., Niranjan M. S., Chaluvaraju K. C., Jamakhandi C. M. and Dayanand K., (2010) synthesis and antimicrobial study of some Schiff basees of sulfonamides, J. Current Pharm. Res., 1 :39-42.
[11] Sreenivasa G. M., Jayachandran E., Shivakumar B., Jayaraj K. K. and Vijikumar M. M., (2009) Synthesis of bioactive molecule chlorobenzothiazole compressing potent heterocyclic moieties for anthelmintic activity, Arch. Pharm. Sci. and Res., 1 (2) : 150-157.
[12] Al-Azzawi A. M. and Hmd A. S., (2014) Synthesis and antimicrobial screening of new naphthalimides linked to oxadiazole ,thiadiazole and triazole cycles. Int. Res. Pharm. Chem., 4(2) :283-290.
[13] Al-Azzawi A. M. and Abd Al-Razzak M. S., (2013) Synthesis, characterization and antimicrobial screening of new Schiff bases linked to phthalimide, Int. Res. Pharm. Chem., 3 (3) :682-690.
[14] Al-Azzawi A. M. and Abd Al-Razzak M. S.,(2011) Synthesis, characterization and antimicrobial activity of several new Schiff bases linked to phthalimide moiety, Kerbala J. Pharm. Sci., 2:124-133.
[15] Silverstein R. M., Basler G. C. and Kiemel D. J., 7th Ed. John Wiley and Sons, N. J. (2005).
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