Naproxen Sodium Release from Poly(acrylic acid-co- N-vinyl-2-pyrrolidone) Hydrogels | ||
| journal of al-qadisiyah for pure science(quarterly) | ||
| Article 1, Volume 16, Issue 3, July 2016, Pages 64-77 PDF (0 K) | ||
| Author | ||
| Nadher D. Radhy | ||
| Abstract | ||
| Copolymer hydrogels of acrylic acid (AA) and N-vinyl-2-pyrrolidone (NVP), crosslinked with 1,4-butanediol dimethacrylate (BDDMA), were prepared by radical copolymerization. The chemical structures of copolymer hydrogels were analyzed by Fourier transform infrared spectrometer (FTIR) and H NMR spectroscopy. The swelling ratio (Rs) was measured for four types of hydrogels structures, in three different media pH 1.2 , 4 and 7.4 at 370C as a function of time. A Naproxen Sodium is used as a model drug to investigate the drug release profile of the hydrogels. The concentration of drug released was measured on UV-Vis spectrophotometer. Results indicated that the swelling ratio and drug release is increase concentration decrease of crosslinked agent and pH increase. | ||
| Keywords | ||
| hydrogels; Acrylic acid; vinyl; pyrrolidone; swelling ratio; Naproxen Sodium; drug release | ||
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