Synthesis and Biological Evaluation of Some Tetrahydroquinoline Compounds Derived from 4- Aminobenzenesulfonamid | ||
| Journal of University of Anbar for Pure Science | ||
| Article 11, Volume 8, Issue 1, April 2014, Pages 41-45 | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2014.122628 | ||
| Authors | ||
| Mohammed A. Kadhim1; Sameaa J. .Khammas2 | ||
| 1University of Anbar, College of Education for Pure Science . | ||
| 2University of Baghdad college of science for women | ||
| Abstract | ||
| In the present study, five compounds of 1,2,3,4-tetrahydroquinolines derivatives of 4- Aminobenzenesulfonamid were prepared through Imines – Diels – Alder reaction by reacting Schiff bases with cinnamic acid and Bf3 Et2O in ethanol. The Schiff bases were synthesized by treating various aromatic aldehydes with 4-Aminobenzenesulfonamid. The structures of the synthesized compounds were determined on the basis of their FTIR, UV and C.H.N spectral data. The in vitro antibacterial and antifungal activities of the compounds were evaluated by paper disc diffusion method. The synthesized compounds were determined by using the Minimum Inhibitory Concentration (MIC).Significant antimicrobial activities were observed for some compounds of the series | ||
| Keywords | ||
| synthesis; Biological evaluation; Tetrahydroquinoline; Aminobenzenesulfonamid | ||
| References | ||
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1. P, N. B., B. J. W.; M.C., J. D., M.o, M. H. G. (1986). J. Org. Chem., 51: 5476.
2. P, N. B., B., J. W.; Munro, M. H. G.(1988).Tetrahedron,44: 1727.
3. Nishiyama, S.; Ch., J. F.; Tao, X. L., Y., S. (1991). Tetrahedron Lett., 32: 4151. | ||
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