Antinociceptive Effect of Peppermint in Mice | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 9, Issue 2, December 2016, Pages 2565-2568 PDF (0 K) | ||
| Authors | ||
| Rasheed Muhsin; | ||
| Abstract | ||
| background: Menthol the primary component of the essential oil of peppermint is thought to be responsible for most. of its properties. It is thought to provide. a local anesthetic action and be of use in musculoskeletal pain, but with no. experimental evidence for analgesic activity with respect to the. leaves of this plant. Methods: Forty Swiss mice of either. sex (weighing 20-25grams) was used in this study, divided into five. groups each with eight animals. Group 1: receiving distilled water. Groups 2, 3&4: pre-treated. with aqueous extract of peppermint in doses 50, 75 and 100 mg/kg, orally. Respectively, and Group 5: pre-treated with .standard drug (Ibuprofen 100 mg/kg), orally. The analgesic activity. was determined by radiant heat Tail-flick method in mice and converted (using special equation) to maximum. possible effect. The results are reported as mean ± S.E.M and analyzed with ANOVA followed by Dunetts multiple comparison test. The results. were significant at p<0.05. Results: The Maximal. Possible Effect (%MPE) was significant when peppermint was. used in a dose of 100mg/kg, and not significant when was used in doses of 50mg/kg &75mg/kg as compared. to % MPE of Ibuprofen. Conclusion: Peppermint has. analgesic effect when given orally as aqueous extract of dried leaves. in a dose of 100mg/kg in mice. | ||
| Keywords | ||
| Peppermint; analgesic activity; aqueous extract; maximum possible effect | ||
|
Statistics Article View: 141 PDF Download: 106 |
||