Injectable Bulking Agents in the Treatment of Female Stress Urinary Incontinence due to Intrinsic Sphincter Deficiency | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 9, Issue 2, December 2016, Pages 2470-2478 PDF (0 K) | ||
| Authors | ||
| Ahmed H. Al-Shareef; Yasamin Hamza Sharif Al-Shibany; Alaq Saeed Abdulhussain | ||
| Abstract | ||
| b ackground and objectives: Stress urinary incontinence(SUI) has a significant impact on the quality of life for many women and it is caused by weakening of pelvic floor muscle that support the bladder and urethra. It affects (1 of 3 women) and it is often associated with childbearing and can be defined as a brief involuntary loss of urine due to increase abdominal pressure in the absence of detrusor activity. Injectable agents have been used to manage SUI for more than a decade but their application has been limited by placement, durability, antigenicity and other compatibility issues. Therefore, there is a continuous development of techniques and materials for newer bulking agents. Our study was to evaluate the efficacy and safety of the urethral injectable agent DEXELL SUI in women with stress urinary incontinence after 12 months follow up. Materials and Methods: A prospective, cohort study conducted in Iraq from January 2014 – January 2016 and data for the study was including 25 female patients (20 -52) years old with SUI due to intrinsic sphincter deficiency attending the department of Obstetrics and Gynecology, Urological department, out patients and privet clinic in Al-Diwaniya and AL-Najaf cities. All patients were treated with DEXELL SUI periurethral injection under local anesthesia. Patients were evaluated for efficacy and safety parameters at 6 weeks visit, 3 months and 12 months visit after injection. Results: The mean stamey incontinence grade significantly decreased from 1.92 at baseline visit to 0.28 at 12 months visit(P<0.001).None of the patients were dry at baseline,64% were dry at 6 week visit, 80% at 3 months visit and 72% at 12 months visit. There was significant reduction in number of pads used per 6 hours per day from 2.44 to 0.40 after 12 months visit(P<0.001). Eight patients (32%)developed minor complications related to injection procedure and all were treated successfully. Conclusion: DEXELL SUI is effective urethral bulking agents with moderate adverse effects used in the treatment of female SUI due to intrinsic sphincter deficiency with less invasive technique. | ||
| Keywords | ||
| Stress urinary incontinence; Intrinsic sphincter deficiency; Urethral bulking agent | ||
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