Green Synthesized Silver Nanoparticles using Cro- cus sativus L Extract after reduces Prehepatocellular Carcinoma In Rats | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 9, Issue 2, December 2016, Pages 181-186 | ||
| Authors | ||
| ; Lamia A. AL-Mashhedy; Neran Ali Thamer | ||
| Abstract | ||
| In this study, the effects of green synthesized silver nanoparticles (Ag NPs) using crocus sativus L were investigated on the liver tissues of white albino rats after induced the prehepatocellular carcinoma using diethylnitrosamine. Thirty male albino rats weight (150-200) gm ,were used by dividing them into ve groups, each group contains 6 rats. Group 1(control group) was given food and water like other groups by liberty. Group 2 was intraperitoneal injected with single dose of diethylnitro- samine200 mg/kg b. wt . Group 3 was intraperitoneal injected with a AgNPs 200 mg/kg b. wt for six weeks . Group 4 was intraperitoneal injected with single dose of diethylnitrosamine 200 mg/kg b. wt followed by, intraperitoneal injected with a AgNPs 200 mg/kg b. wt for six weeks . Group 5 was intraperitoneally injected with a AgNPs 200 mg/kg b. wt for six weeks ,followed by intraperitoneal injected with single dose of Diethylnitrosamine200 mg/kg b. wt . All animals were sacri ed at the end of experiment. The histophathological studies revealed that group 1 have normal hepatocyte. Group2 have sever necrosis, fatty change , atypical cells and bile duct proliferation . Group 3, have normal hepatocyte cell with mild necrosis. Groups 4, have certain area of necrosis , in ammatory cells in ltration ,congestion and mild fatty change, no atypical cells were seen. Group 5 the liver section showing certain area of necrosis , in ammatory cells in ltration ,mild fatty change and no atypical cells. | ||
| Keywords | ||
| Nanoparticles; silver nanoparticles; Albino male rat; prehepatocellular carcinoma | ||
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