Synthesis, Characterization, and Biological Properties of Cr(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes Derived from 1,3-Oxazol-5-(4H)-One | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 57, Issue 3, August 2016, Pages 1629-1638 | ||
| Authors | ||
| Rehab Abdul Mahdi Al-Hassani; Sinan Midhat Mohamed; Anaam Majeed Rasheed; Asmaa Abdul Baqi Maryoosh; Ali Abdul Rasool Hussein | ||
| Abstract | ||
| New 1,3-oxazol-5(4H)-one(3) was synthesized by cyclization of[(4-Methyl phenyl-carbonyl)amino]acetic acid (2). The starting materials were readily obtained by acylation of 2-amino acetic acid (Glycine) with 4-methyl phenyl chloride .Imidazole(4) was synthesized by reaction of compound (3) with hydrazine hydrate (99%). Compound (4) was isolated and characterized by 1HNMR , FTIR , uv-vis spectroscopy and elemental analysis (C.H.N). Compound (4) has been used as a ligand (L) to prepare a number of metal complexes with Cr(III), Mn(II), Co(II), Ni(II) , Cu(II) and Zn(II). The prepared complexes were isolated and characterized by FTIR and Uv-vis spectroscopy elemental analysis (C.H.N), flame atomic absorption technique, as well as magnetic susceptibility and conductivity measurements. The biological activity of the synthesized ligand (L) and its metal complexes were screened against the bacteria (S. aureus, B.Subtilis) and fungi (C.albicans) at the minimum inhibitory concentration method. Amoxiciline drug was used for comparison under similar conditions. They showed remarkable biological activity | ||
| Keywords | ||
| Oxazol; imidazole; Transition metal complexes; Spectroscopy; Biological activity | ||
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