Synthesis, characterization, antimicrobial and antifungal evaluation of novel [1,3]-Benzodiazepine derivatives incorporated with nicotinic acid under Microwave irradiation | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 19, Issue 5, August 2014, Pages 75-86 | ||
| Authors | ||
| Mustafa R.Al-Bayati; Mohammed G.Aldulme; Khalid abdul-aziz Al-badrany | ||
| Abstract | ||
| Abstract A series of some newly [1,3]-benzodiazepine derivatives of Nicotinic acid hydrazide have been synthesized by treating the hydrazide-hydrazones of nicotinc acid hydrazide with two different phthalimide, glycene phthalimide and p-amino benzoic acid phthalimide using the microwave irradiation technique to give a newly seven-membered ring containing two nitrogen atoms. This method is facile and efficient and afforded 1,3- Benzodiazepine derivatives in an excellent yield. The structures of synthesized compounds were established on the basis of IR, 1H-NMR, 13C-NMR and mass spectral data. The microbial inhibitory effect of the new agents has been evaluated in vitro against Gram-positive and Gram-negative bacteria as well as antifungal activity. The most significant antimicrobial activity was obtained with compound 18 in addition to the antifungal activity. | ||
| Keywords | ||
| Nicotinic acid hydrazide; benzodiazepine; seven membered ring; Microwave irradiation | ||
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