Study the effect of supplementation of two types' of omega-3 poly | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 19, Issue 1, April 2014, Pages 75-82 | ||
| Authors | ||
| Mustafa Nema A. Ali; Farah A. Rasheed | ||
| Abstract | ||
| Abstract Asthma is a chronic disorder ofthe airways with underlying inflammation and oxidative stress. Malondialdehyde (MDA) - the lipid peroxidation product- level increases in inflammatory diseases and used as a common oxidative stress marker . Albumin and bilirubin, uric acid ; are components of antioxidant defense system. Omega-3polyunsaturated fatty acids supplementations lead to decrease the inflammatory mediators thereby decrease oxidative stress in asthmatics. Thirty seven asthmatic patients (20 females and l7 males) were involved compared with 37 healthy controls. Plasma samples analyzed for total MDA, albumin bilirubin, and uric acid before and after 3 weeks of supplementation of two types omega -3 polyunsaturated fatty acids (300mg/day) . After 3weeks of supplementation the MDA level change along supplementation period (p< 0.05), but it still significantly differ fiom control (p<0.01), albumin and bilirubin retum to conhol level with non-significant difference flom control, while uric acid increase significantly. These results indicate the decrease oxidative stress situation since MDA levels decrease while endogenous antioxidant molecules (albumin, bilirubin , and uric acid) levels raised leading to conclude the valuable omega-3 fatty acids supplementation for asthmatic patients | ||
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