Immunohistochemical Expressions of AKT, ATM and Cyclin E in Oral Squamous Cell Carcinoma
|Journal of baghdad college of dentistry|
|Article 1, Volume 28, Issue 3, September 2016, Pages 44-51|
|Afrah A. Khalil; Seta A. Sarkis|
|Background: Understanding the pathogenesis and molecular basis of Oral Squamous Cell Carcinoma (OSCC) has|
increased rapidly over the past few years that is essential to improve patient's prognosis and treatment modalities.
The purpose of this study to evaluate the Immunohistochemical expressions of AKT, ATM, AND Cyclin E in oral
squamous cell carcinoma
Materials and methods: This study was performed on a forty formalin-fixed paraffin-embedded blocks which
histopathologically diagnosed as Oral Squamous Cell Carcinoma. All cases were collected from the
Histopathological Laboratory from patients treated surgically at Maxillofacial surgery Department at Ramadi
Teaching Hospital, Iraq.
Results: The immunohistochemical staining of AKT showed positive expression in 38 (95%), ATM showed positive
expression in 38(95%) and Cyclin E showed positive expression in 36(90%) of the cases.
Conclusion: A statically significant correlation was found regarding the immunohistochemical expression of AKT with
tumor grade and stage, Cyclin E with the age group and ATM with the clinical appearance
|Squamous cell carcinoma; oral cancer; Immunohistochemistry; prognosis; expression|
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