The correlation between HLA class II and β-thalassemia major in Al-Karama teaching hospital | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 58, Issue 4, December 2016, Pages 366-370 | ||
| Author | ||
| Sarmad M. Zeiny | ||
| Abstract | ||
| Background: Thalassemia is a form of inherited autosomal recessive blood disorder characterized by abnormal formation of hemoglobin. Objective: Determine frequencies & association of HLA class II alleles (DRB1& DQB1) in Iraqi β-thalassemia major patients. Patients: seventy unrelated randomly selected β-thalassemia major patients, and one hundred unrelated randomly selected healthy individuals, composed the control group. Methods: low resolution PCR-SSO (Sequence Specific Oligonucleotide) technique was used for HLA typing. Results: HLA DQB1*5 give significance importance as an etiological risk factor for β-thalassemia major; HLA DQB1*3 give significance importance as a preventive risk factor for β-thalassemia major. Conclusion: The positive association of HLA DQB1*5 and DQB1*3 with β-thalassemia major may have the possibility that these antigens, or the genes encoding them, are closely linked with other possible susceptibility genes. | ||
| Keywords | ||
| Thalassemia Major; PCR; SSO; HLA class II | ||
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