The Role of PTEN Gene Deletion In Prostate Cancer In Relation To Proliferative Capability of Malignant Cells | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 13, Issue 3, September 2016, Pages 0-0 | ||
| Authors | ||
| Nabeel Tawfeeq Kammuna; Kaswr Mosa Al-Taraihi; Asaad Abdullhamza Al-janabi | ||
| Abstract | ||
| PTEN gene is a tumor suppressor gene located in 10q23,3 that encode dual- specificity protein and lipid phospatase with tensinhomologe. The PTEN protein signals adjust cell splitting up and express cells to enter normal cell death way. defeat of PTEN leads to over –foundation of AKt, which in circle , is related with unrestrained cell production. In this cross section study, we examined 50 paraffin-embedded blocks belongs to 50 patients with proved prostate cancer, All slides subjected to IHC KI67 Ab ( which is a parameter of proliferative activity of malignant cells), and to 1 molecular study of PTEN gene in all tissues by using CISH technique. The association between PTEN gene status examined by CISH technique with KI67 score performed by IHC technique , is highly significant, in that we get 71.43% (25/35) of no deletion cases had KI67 score ≤10% of cells, while in cases with PTEN gene deletion , we had 73.33% (11/15) of cases carry KI67 score >10% of cells. | ||
| Keywords | ||
| PTEN; phosphatase and tension; Akt; Antigen Kinase Thymoma; CISH; chromogenic in situ hybridization; FISH; Flurescent in situ hybridization | ||
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