Synthesis and Biological Evaluation of Trehalose-Schiff base Fragments of Cell Wall in Mycobacterium tuberculosis on Some Microorganisms | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 27, Issue 3, July 2016, Pages 24-28 | ||
| Author | ||
| Mohsin Omar Mohammed | ||
| Abstract | ||
| A series of α,α`-D- trehalose-shiff base had been prepared through the trityl protection of the two primary hydroxyls of α,α`-D-trehaloses, benzoylation, removal of the trityl protective group, mesylation, azidation, catalytic hydrogenation in the presence of hydrochloride, coupling reaction with a variety of aromatic aldehydes, and subsequent debenzoylation. All new compounds were characterized by 1H NMR, FTIR spectroscopy. Synthesised compounds were screened for antimicrobial bacterial activity against several pathogenic Microorganisms, namely Escherichia coli, Staphylococcus aureus, Mycobacterium phlei, Bacillus subtilis, Candida albicans and Aspergillus niger, and they showed enhanced antimicrobial activity. | ||
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