Synthesis of Some New Schiff Bases and Reaction with Urea & Thiourea Derivatives from 2-Amino -1,3,4-thiadiazole-5-thiol | ||
| journal of the college of basic education | ||
| Article 1, Volume 22, Issue 94, June 2016, Pages 33-46 | ||
| Author | ||
| Sanaa Abdul-Sahib Abdul-Kareem Al-Mansori Chemistry Dept. College of Science for Women University of Baghdad | ||
| Abstract | ||
| In this paper new Schiff bases and tetrazole derivatives of 2-Amino-1,3,4-thiadiazole- 5-thiol have been prepared.2-Amino-1,3,4-thiadiazole-5-thiol was prepared by the reaction of thiosemicarbazide with carbon disulfide in alcoholic sodium carbonate solution .The new Schiff bases derivatives [2_5] were prepared by condensation of aldehyde group with 2-Amino-1,3,4-thiadiazole-5-thiol (P-Nitrobenzeldehyde ,M- Nitrobenzeldehyde, P-Hydroxybenzeldehyde, , 4-Hydroxy 3-Methoxy benzeldehyde) . The resulting Shiffbase were Reaction with acetic anhydride [6-9] and this derivatives reaction with urea and thiourea intetrahydrofuran{10-17}. All new synthesized derivatives were identified by their melting points, and FT-IR,U.V spectra. Some products were identified in elemental analysis and Chledal analysis .They have long been known to possess hypnotics activities and it is hoped that our compounds would do so. | ||
| Keywords | ||
| Synthesis of Some New Schiff Bases and Reaction with Urea; amino; thiadiazole; thiol | ||
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