Naji Rashid, Q., Hamza Bakir, M., Omar Baban, S. (2016). Spectrophotometric determination of Methyldopa in pure form and in the pharmaceutical preparations. Alustath, 11(1), 67-77.
Qabas Naji Rashid; Mohsin Hamza Bakir; Shirwan Omar Baban. "Spectrophotometric determination of Methyldopa in pure form and in the pharmaceutical preparations". Alustath, 11, 1, 2016, 67-77.
Naji Rashid, Q., Hamza Bakir, M., Omar Baban, S. (2016). 'Spectrophotometric determination of Methyldopa in pure form and in the pharmaceutical preparations', Alustath, 11(1), pp. 67-77.
Naji Rashid, Q., Hamza Bakir, M., Omar Baban, S. Spectrophotometric determination of Methyldopa in pure form and in the pharmaceutical preparations. Alustath, 2016; 11(1): 67-77.

Spectrophotometric determination of Methyldopa in pure form and in the pharmaceutical preparations

Tikret Journal of Pharmaceutical Sciences
Article 1, Volume 11, Issue 1, December 2016, Pages 67-77
Authors
Qabas Naji Rashid; Mohsin Hamza Bakir; Shirwan Omar Baban
Abstract
A simple, rapid and sensitive spectrophotometric method for determination of methyldopa (MD) using 4-chloro-7-nitrobenzo-2-oxa-1, 3-diazole (NBD-Cl) as reagent in an alkaline medium (pH 12.3). Absorbance of the resulting brown-colored product is measured at 470 nm. Beer’s Law is obeyed in a concentration range of (1.6-17.6 µg/mL) with molar absorptivity (1.9337×104 L/mol.cm), correlation coefficient 0.9988, and the limit of detection (5.536×10-3 µg/mL). The method has been successfully applied to the determination of Methyldopa in pharmaceutical preparations.
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