Ali, B., Wassan, , matne - M, K., Hussein-R-hammod, (2016). Synthesis and Biological Activity Evolution of 5-amino-1,3,4-thiadiazole- 2-thiol Compound and Some Derivatives. Alustath, 12(4), 51-67.
B- Ali; Wassan; Khaled matne - M; Hussein-R-hammod. "Synthesis and Biological Activity Evolution of 5-amino-1,3,4-thiadiazole- 2-thiol Compound and Some Derivatives". Alustath, 12, 4, 2016, 51-67.
Ali, B., Wassan, , matne - M, K., Hussein-R-hammod, (2016). 'Synthesis and Biological Activity Evolution of 5-amino-1,3,4-thiadiazole- 2-thiol Compound and Some Derivatives', Alustath, 12(4), pp. 51-67.
Ali, B., Wassan, , matne - M, K., Hussein-R-hammod, Synthesis and Biological Activity Evolution of 5-amino-1,3,4-thiadiazole- 2-thiol Compound and Some Derivatives. Alustath, 2016; 12(4): 51-67.

Synthesis and Biological Activity Evolution of 5-amino-1,3,4-thiadiazole- 2-thiol Compound and Some Derivatives

Diyala Journal For Pure Science
Article 1, Volume 12, Issue 4, October 2016, Pages 51-67
Authors
B- Ali; ; Khaled matne - M;
Abstract
In this work , new of 5-amino-1,3,4-thiadiazole- 2-thiol derivatives were synthesized (S1-S19), through the reaction of 5-amino-1,3,4-thiadiazole- 2-thiol with p-hydroxy acetophenone to form azo dyes (S2), Chalcones were synthesized by reaction of compound (S2) with different aromatic aldehyde(S3-S6). Compounds (S7-S17) were finally synthesized by ring closure by hydrazine and some hydrazine derivatives . The newly synthesized compounds were confirmed by FT-IR-spectra and H1-NMR, and they showed good agreement with the proposed structures. Also the biological activity of some of the test compounds were investigated in vitro, against some bacterial.
Keywords
amino; thiadiazole; thiol; azo dyes; Chalcones; ring quinary chalcones
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