A Study on Functional Tests and Histological Changes in Liver and Kidney of Laboratory Male Mice Treated With Ammonium Chloride | ||
| Magazine of Al-Kufa University for Biology | ||
| Article 1, Volume 7, Issue 3, December 2015, Pages 335-345 | ||
| Authors | ||
| Faris Shaker Kata; Majda I. Abd AL-Majeed; Ali A. AL- Ali | ||
| Abstract | ||
| The present study was aimed to investigate the effects of ammonium chloride on levels of urea, creatinine, total protein, lipid ( triglyceride and cholesterol ), and liver marker enzymes such as AST, ALT and ALP. It is also this study was carried out investigate the influence of ammonium chloride on liver and kidney tissues. Oral administration of ammonium chloride (4mg/ay) caused a significantly increase in the levels of AST and a significant decreased the level of ALP and total protein in mice. Treated mice with ammonium chloride at dose 2,4mg/day for 21day showed a significant decrease in levels of creatinine ,triglyceride and cholesterol , while ALT and urea had not affect at two doses of ammonium chloride. Histological changes of liver and kidney in mice which treated with 4mg/day of ammonium chloride revealed hypertrophy and irregular of nucleus shape, degeneration of cytoplasm, necrosis, congestion of sinusoid, cell swelling , bleeding, and infiltration of inflammatory cells . | ||
| Keywords | ||
| Ammonium chloride; liver; kidney; AST; urea; triglyceride | ||
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