Synthesis of some Heterocyclic Compounds Derived from(5,6 diphenyl-1,2,4-triazine-3-thiol( | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 27, Issue 2, April 2016, Pages 7-13 | ||
| Author | ||
| Nisreen Kais Abood | ||
| Abstract | ||
| The present work describe the synthesis of new heterocyclic compounds starting from reaction 5,6 diphenyl-1,2,4-triazine 3-thiol with ethyl chloro acetate afforded compound (1),then treatment with thiourea or urea afforded compound (2,3). p-Bromo phenacyl bromide react with compounds (2,3) afforded compounds (4,5),treatment compound (1) with hydrazine hydrate to afforded 2-(5,6 di phenyl 1,2,4-triazin-3yl thio)aceto hydrazide compound (6) . Azomethines (7,8) were prepared through reaction of compound (6) with aromatic aldehyde, then (7,8) converted to thaizolidinone derivatives (9,10) after treatment with 2-mercapto acetic acid Reaction of compound (6) with phenyl iso thiocyanate to give compound(11) and the product (11)react with ethyl chloro acetate afforded compound (12) , then reaction (5,6 di phenyl1,2,4- triazin 3-thiol with chloro acetic acid gave compound (13)followed by refluxing (13) with ortho phenylenediamine gave compound (14). All compounds were confirmed by their melting point, FT-IR spectrum,1HNMR spectrum for some of them. | ||
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