Spectrophotometric Determination of Paracetamol by Diazotization and Coupling Reaction with Anthranilic Acid | ||
| Ibn Al-Haitham Journal For Pure And Applied Science | ||
| Article 1, Volume 29, Issue 2, August 2016, Pages 409-420 | ||
| Authors | ||
| Mohammed S. Abdul- Raheem; Khalaf F. Alsamarrai | ||
| Abstract | ||
| This paper concerned with development of a spectrophotometric method for the determination of paracetamol, based on the diazotisation and coupling reaction with anthranilic acid in basic medium, to form an intense yellow coloured, water-soluble and stable azo-dye which shows a maximum absorption at 421nm. Beer’s law is obeyed over the concentration range of 1.0-10 μg/ml; with molar absorptivity of 2.1772×104 L.mol-1.cm-1 and Sandell’s sensitivity index 6.9446 μg.cm-2. The method has been applied successfully for the determination of paracetamol in pharmaceutical formulation. | ||
| Keywords | ||
| Spectrophotometric; Determination; paracetamol; Dosage forms; d diazotization and coupling; anthranilic acid | ||
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