R. Fadhel, S., I. Abdulla, N., D. Sulaiman, I. (2016). The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline. Alustath, 25(1), 42-49.
Sahar R. Fadhel; Najwa I. Abdulla; Intidhar D. Sulaiman. "The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline". Alustath, 25, 1, 2016, 42-49.
R. Fadhel, S., I. Abdulla, N., D. Sulaiman, I. (2016). 'The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline', Alustath, 25(1), pp. 42-49.
R. Fadhel, S., I. Abdulla, N., D. Sulaiman, I. The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline. Alustath, 2016; 25(1): 42-49.

The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline

Iraqi Journal of Pharmaceutical Sciences
Article 1, Volume 25, Issue 1, June 2016, Pages 42-49
Authors
Sahar R. Fadhel; Najwa I. Abdulla; Intidhar D. Sulaiman
Abstract
A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 nm. The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (0.5-45.0 μg.mL-1) with a molar absorptivity of 1.5777×104 L.mol-1.cm-1. The limit of detection was 0.3148 μg.mL-1 and Sandell’s sensitivity value was 0.0198 μg.cm-2. The proposed method has been applied successfully to the determination of olanzapine in tablet pharmaceutical preparations.
Keywords
Spectrophotometry; Olanzapine; diazotization; nitroaniline; tablet dosage form
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