A. Bakir, W., Y. Yaseen, N., H. Ismail, N., W. Abd, D., A. Hasson, H. (2016). Metalloproteinase-7 (MMP-7) and their clinical rel- evance in urinary bladder cancer. Alustath, 9(1), 57-61.
Wasan A. Bakir; Nahi Y. Yaseen; Noor H. Ismail; Dina W. Abd; Haidar A. Hasson. "Metalloproteinase-7 (MMP-7) and their clinical rel- evance in urinary bladder cancer". Alustath, 9, 1, 2016, 57-61.
A. Bakir, W., Y. Yaseen, N., H. Ismail, N., W. Abd, D., A. Hasson, H. (2016). 'Metalloproteinase-7 (MMP-7) and their clinical rel- evance in urinary bladder cancer', Alustath, 9(1), pp. 57-61.
A. Bakir, W., Y. Yaseen, N., H. Ismail, N., W. Abd, D., A. Hasson, H. Metalloproteinase-7 (MMP-7) and their clinical rel- evance in urinary bladder cancer. Alustath, 2016; 9(1): 57-61.

Metalloproteinase-7 (MMP-7) and their clinical rel- evance in urinary bladder cancer

Iraqi Journal of Cancer and Medical Genetics
Article 1, Volume 9, Issue 1, June 2016, Pages 57-61
Authors
Wasan A. Bakir; Nahi Y. Yaseen; Noor H. Ismail; Dina W. Abd; Haidar A. Hasson
Abstract
Background: metalloproteinase-7 (MMP-7) is produced by stromal cells and by tumor cells,and overexpressed in a variety of epithelial and mesenchymal tumors. The aim of this study was to assessthe association of MMP-7 with clinical-pathological factors and to evaluate its diagnostic value in patients with bladdercarcinoma.
Methods: Expression of MMP-7 was evaluated in tumor tissues of 32 urinary bladder cancer cases and 30 control groupswere xed in formalin and embedded in paraf n blokes, then analyzedby in situ hybridization technique.
Results: Expression of MMP-7was signi cantly higher in tumor compared to normal samples. The expression signi cantly associated with tumor grade and muscle invasion.
Conclusion: MMP-7 may play an essential role in pathogenesis of bladder cancer. And may helpful to conventional diagnostic tools in malignancy as diagnosis.
Keywords
MMP; Bladder carcinoma
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