The Effect of Oxytocin on Sialic Acid Content of some Immune Cells in Albino Mice | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 12, Issue 3, August 2016, Pages 54-62 | ||
| Authors | ||
| Zainab Thamer Showait Al-Assady; Ali Hussain Edhaia; Linda S. Fawzi | ||
| Abstract | ||
| Using (144) Albino male mice of two age groups (4 and 5) weeks old, were injected intraperitonealy with three concentrations of the hormone oxytocin (0.5, 1.0, 2.0) IU/ mouse, at a dose of 2.0 ml. The control group was injected o.2 ml (PBS), The results showed a significant reduction in the TSA level in serum and splenic cell homogenate after treatment with the three concentrations. The highest reduction was observed at 2.0 IU/ mouse (170.63 and 233.98 μg/ ml) for both age groups, respectively. In spleen the highest reduction was observed at the concentration 2.0 IU/ mouse (33.11 and 34.55) % of control value respectively. While the bone marrow cell homogenate showed elevated level of TSA at the concentration 1.0 IU/ mouse in four week old mice, and at the concentration 0.5 IU/ mouse in mice five weeks old. However a reduction in its level was observed at the concentration 2.0 IU/ mouse. This conclude that there is an obvious effect of oxytocin on the sialic acid content and metabolism regarding to the functions of some immune cells in both the spleen and bone marrow. | ||
| Keywords | ||
| Sialic Acid; Oxytocin; White Blood Cells | ||
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