The Relationship Between The Infection With E. histolytica and Some Blood Parameters | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 12, Issue 1, February 2016, Pages 133-142 | ||
| Authors | ||
| Rawaa Abdulkhaleq Hussein; Mohammed Jasim Shaker | ||
| Abstract | ||
| Background: Infection with Entamoeba histolytica is a major health problem in many tropical and subtropical areas of the world, especially in developing countries. The factors that control the pathogenesis of E. histolytica are not completely understood. However, key features are the ability of the organism to lyse host cells and cause tissue destruction, with induced immune responses occurring in invasive disease. Up to now, few reports about blood alterations induced by E. histolytica infection have been described. Objective: The aim of the present study was to evaluate the relationship between the infection with E. histolytica and some blood parameters Patients and methods: A total of 320 male and female patients presented with infected diarrhea to the Central Teaching Hospital for Pediatric and some Medical Centers in Baghdad city – Iraq were examined, during the period from April to October, 2014. The age of patients ranged from 1-50 years. Forty five healthy parasite-free individuals used as a control group. Stool samples were collected from patients for direct microscopic examination , then the blood parameters evaluated were (RBCs, HB, PCV, MCV, MCH, MCHC, PLT, TLC, Neutrophile, Lymphocyte and mixed cells) in the patient's blood, using Sysmex instrument. Results: In this study 60 patients out of 320 patients confirmed to be positive for E. histolytica. The results showed a significant decrease (P<0.05) in RBCs count, level of Hb, PCV, MCV and MCHC in E. histolytica infected patients in comparison to healthy control group. In addition, the total leucocyte count and differential type of neutrophil, lymphocyte and mixed cells (monocyte, eosinophile, basiophile) increased significantly (P < 0.05) in patients infected with E. histolytica in compared to healthy control. Conclusion: The present study confirmed the existence of a relationship between the infection with E. histolytica and changes in blood parameters indices involved in anaemia. This may be an evident proof that parasitic infections have an adverse effect on haemoglobin, packed cell volume, and mean cell haemoglobin concentration, and immune response. | ||
| Keywords | ||
| Blood parameters; Entamoeba histolytica; Parasitic infection | ||
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