Synthesis a Series of 1,3,4-Thiadiazole Derivatives and Investigate Their Biological Activity | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 12, Issue 1, February 2016, Pages 122-132 | ||
| Authors | ||
| Salih Mahdi Salman; Mustafa K. Shneshil; Waseela Abdul Reda | ||
| Abstract | ||
| Eight compounds of new 1,3,4-thiadiazole biologically active for the series1,4-di(5-(4-substitutedphenyldiazenyl)-1,3,4-thiadiazol-2-yl) benzene were prepared through the reaction of terephthalic acid with thiosemicarbazide .The product was coupled with substituted benzene through a diazotization reaction. The synthesized compounds (2-9) were identified using the analytical and spectral means. The biological activity for those compounds was investigated against three types of bacteria Escherichia coli (Gram negative bacteria), Enterobacter (Gram- negative bacteria) and Staphylococusaurens (Gram-negative). | ||
| Keywords | ||
| Thiadiazol; biological active compounds; diazotization reaction | ||
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