Synthesis and Characterization of Some New 4-Oxothiazolidine-2-Carboxylic Acid Derivatives With the Evaluation of Their Biological Activity | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 12, Issue 1, February 2016, Pages 43-64 | ||
| Author | ||
| Abstract | ||
| Reaction of 2-alkylthiazolidine-4-carboxylic acid [1] with methanol in presense drops of sulfuric acid gave the ester: methyl 2-alkylthiazolidine-4-carboxylate [2], then converted this ester to the acid hydrazide: 2-alkylthiazolidine-4 carbohydrazide [3] which was reacted with glyoxylic acid to give Schiff base: 2-[2-(2-alkylthiazolidine-4-carbonyl)hydrazono]acetic acid [4]. Schiff,s bases (4) were reacted with thioglycolic acid to give 3-(2-alkylthiazolidine-4- carboxamido)-4- oxothiazolidine-2 - carboxylic acid [5]. The spectral methods of the prepared compounds were characterized by FT.IR, 1HNMR ( just for compounds 5), and Uv-Vis, besides melting points were recorded and the purity was checked through T.L.C. technique. Antibacterial activity for some of the synthesized compounds were screened. | ||
| Keywords | ||
| heterocyclic compounds; Sulfur amino acid; thiazolidine; Carboxylic Acids; Schiff; s bases | ||
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