Relationship of Interleukin – 8 levels with some hematological and biochemical parameters in patients with chronic hepatitis B and C infection | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 10, Issue 4, December 2014, Pages 11-24 | ||
| Authors | ||
| Hameed M. Majeed; Mazin Razooqi Mohammed; Zeena A. Abd Al-Razak | ||
| Abstract | ||
| Infection with hepatitis HBV and HCV affects the liver and results in abroad spectrum of disease outcomes . The role of any given cytokine may be specific or overlapping to generate downstream effects that result from a maze of complex interactions . We evaluated the association between IL- 8 levels of patients with HBV , HCV infections and blood induces and some biological parameters. The study was carried on : - 30 patients chronically infected with HBV (12 males + 18 females ) , the mean age of the patients were 34.03 ± 12.78 years old -30 patients infected with HCV ( 17 males + 13 females ) with mean age of the patients 44.86 ± 17.75 years old. - 28 subjects (control) ( 20 males + 8 females ) , mean age of 28.32 ± 9.32 years old had negative HBs Ag and anti-HCV Ab for the duration of 17/9/20112 to 30/12/2012. Blood samples (6ml) were collected , 2ml for hematological measurements and 4 ml to obtain serum after centrifugation and stored at -84c0 in a deep freezer. Results show lower significantly differ between HBV patients and healthy control in RDW% , Neutrophils and Basophils count . While the mean levels of IL – 8 in sera significantly differ between HBV patients and healthy control( 17.72 ± 14.87 , 8.20 ± 3.15 pg/ml respectively In HCV patients there were lower significantly differ in red blood cells count , concentration of hemoglobin , haematocrit % , RDW% ,platelets, white blood cells count , lymphocytes and basophils . The mean levels of IL – 8 in sera and other parameter did not significantly differ between patients and control. Negative relationship between IL – 8 and lymphocytes , eosinophils in patients with HCV rather than HCV patients, also positive relationship between IL – 8 and ALT, AST enzymes. | ||
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