Morphological and Histopathological effect of Dexamethasoe on the Embryo of white Mus musculus mice | ||
| Diyala Journal For Pure Science | ||
| Article 1, Volume 10, Issue 3, August 2014, Pages 103-116 | ||
| Author | ||
| Sundus M. Tayfur | ||
| Abstract | ||
| The present study was designed to demonstrate the Histopathological and congenital malformation effects caused by Dexamethasone drug in the liver of the Swiss mice Mus musculus. In this study (30) pregnant mice were used with weight ranged (25±2) gm , and were divided into two groups, the first group was injected once each two days ,compared to the control group , which was injected normal saline (0.9% NaCl) .The pregnant mice were injected intrapretonialy at organogenesis stage of embryonic development starting from the 10th to 18th day of pregnancy . The used dose was Therapeutic at concentrations of (0.002 mg/kg). Significant decrease in size and yellowish in color was found in the embryos compared to the control, malformation of embryos was observed in the head, as Cranial flexure The abnormalities also included tail aquiline and cured tail at treated concentration. Histological and congenital malformation in embryos of treated mothers included degenerated cells and the presence of macrophage in the treated group once each two days, Inflammation of bile ducts with central vein dilation with liver congestion at the treated doses compared to the control. | ||
| Keywords | ||
| Dexamethasone; Mice embryo; liver | ||
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