Effect of carvedilol on echocardiographic fraction shortening, troponin I, malondialdehyde in trastuzumab treated females with breast cancer | ||
| journal of kerbala university | ||
| Article 1, Volume 12, Issue 0, January 2016, Pages 238-244 PDF (0 K) | ||
| Authors | ||
| Ayad A. Hussein; Amina A. B. Al Dujeli; Fadhil A. Rizij; Ihsan S. Rabeea | ||
| Abstract | ||
| Background: Trastuzumab therapy is effective in HER2 positive breast cancer patients, but it is highly complicated by cardiotoxicity. Objective: To elucidate the possible effects of carvedilol on echocardiographic fraction shortening, serum troponin I and serum malondialdehyde in trastuzumab treated females with HER2 positive breast cancer. Patients and Methods: A total of twenty six females with HER2 positive breast cancer were enrolled in this study. The patients were randomized into two groups, thirteen patients in each group. Group I included patients who received trastuzumab therapy for 8 cycles with 21 days apart. Group II included patients who treated with trastuzumab therapy with carvedilol 3.125 mg, orally, twice daily dose for 8 cycles. Echocardiography was used to measure fraction shortening at zero time, 4th and 8th cycles in both groups. Serum troponin I and malondialdehyde were measured at zero time, 2nd, 4th, 6th and 8th cycles in both groups. Results: Treatment with trastuzumab therapy caused a significant decrement in echocardiographic fraction shortening at an only 8th cycle in comparison to baseline readings (P < 0.05).Combined trastuzumab plus carvedilol caused a significant increase in echocardiographic fraction shortening compared with that of trastuzumab therapy group (P < 0.05). Regarding serum troponin I and malondialdehyde, trastuzumab therapy caused a significant increment in both these markers in comparison to baseline readings (P < 0.05). Combined trastuzumab plus carvedilol caused significant decrement in troponin I and malondialdehyde compared with that of trastuzumab therapy group (P < 0.05). Conclusion: Carvedilol causes significant increment in echocardiographic fraction shortening and significant decrement in serum troponin I and malondialdehyde in trastuzumab treated patients. | ||
| Keywords | ||
| Carvedilol; Trastuzumab; Cardiotoxicity; Fraction shortening; Troponin I; MDA | ||
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