PROTECTIVE EFFECT OF GINGER (ZINGIBER OFFICINAL) HYDRO ALCOHOLIC EXTRACT ON CADMIUM CHLORIDE INDUCED REPRODUCTIVE TOXICITY IN RATS FEMALE | ||
Euphrates Journal of Agriculture Science | ||
Article 1, Volume 8, Issue 1, March 2016, Pages 8-16 | ||
Author | ||
GhusoonA.k. AL-Neamah | ||
Abstract | ||
The present study was conducted to explore the protective effects of ginger on cadmium chloride induced reproductive toxicity in rats female .40 female adult rats 6-8 weeks old weighing (260 -300 gm.) wasused for the study. Animals was divided into four(10 rats for each groups) groups: Animals in Groups I:served as control and were given distilled water. Group II:was given cadmium chloride at a dose of 0.008 mg/kg B.w once daily for two months by oral gavage tube .Group :III were given cadmium chloride at a dose of 0.008 mg/kg B.w once daily along with ginger extract 200 mg/kg B.w. through oral gavage tube once daily for two months .Group IV: were given ginger extract 200 mg/kg B.w. through oral gavage tube once daily for two months .At the end of the experiment, blood samples were taken via cardiac puncture for follicular stimulating hormone (FSH), luteinizing hormone (LH) analysis .After dissection of animals ,uterui and ovaries were excised for histopathologicalexamination .Results showed that cadmium chloride cause a significant decrease in the levels of sex hormones , and induce toxicopathologicalchanges in genital organsthese changes were ameliorated with extract of ginger. The results of the present study concluded that cadmium chloride -induce toxicopathologicalchanges in uterui and ovaries of rats, which in turn many affected on thereproductive efficiency of animals, thesechanges were improved after co -giving ginger extract which provide a strong evidence for the beneficial role of antioxidants plants in improving theeffect of cadmium chloride toxicity in rats female. | ||
Keywords | ||
Cadmium chloride; Antioxidants; ginger; reproductive toxicity | ||
Statistics Article View: 96 PDF Download: 27 |